NFE2L2 and lipodystrophy: An important feature of the lipodystrophy model was the observation that when the Kp1A/A:: Rosa NIC/NIC::AdiCre mice had an additional deletion of the Nrf2 gene, the beneficial physiology of the Kp1A/A::Rosa NIC/NIC::AdiCre mice against lipodystrophy was lost, leading to diabetes [3].