Thus, we consider that suppressed expression of lipogenesis-related enzymes (i.e., ACC1 and FASN) in the livers of pCAG DA-Nrf2 and pCAG Nqo1 treated RosaNIC/NIC::AdiCre mice is a part of the multifactorial mechanisms underlying improvement of steatosis in the setting of lipodystrophy. Here, FASN is linked to lipodystrophy.