These models include Keap1 constitutive knockout mice, which exhibit postnatal lethality before weaning by malnutrition due to NRF2-driven esophageal constriction [10], heterozygotes that survive, as well as Keap1 knockdown mice (Kp1A/A) [11] with constitutive hypomorphic Keap1 expression without Cre transgene expression [12], or Kp1B/B [13] with wild-type level Keap1 expression before tissue-specific Cre transgene expression. The gene discussed is KEAP1; the disease is nutritional deficiency disease.