Indeed, blood glucose levels were decreased in Kp1A/A::RosaNIC/NIC::AdiCre mice but not in Kp1B/B background mice, suggesting systemic metabolic effects driven by Keap1 hypomorphic expression are one of the key elements in inter-organ communication that is disturbed in the setting of lipodystrophy. This evidence concerns the gene KEAP1 and lipodystrophy.