These results indicate that comparing NRF2 signaling on the fatty liver phenotype between Kp1A/A::RosaNIC/NIC::AdiCre and Kp1B/B::RosaNIC/NIC::AdiCre mice could allow assessments of the role of hepatic as opposed to adipocyte NRF2 on the hepatic symptoms of lipodystrophy in this model. The gene discussed is NFE2L2; the disease is lipodystrophy.