DROSHA and breast carcinoma: Similarly, mutations (rs640831 C/A, rs1110386 G/Aa, rs486732 C/Aa, p.E500, p.R277C, p.Q136a) in RNASEN/DROSHA, a member of the nuclear microprocessing complex and a ribonuclease that cleaves pir-miRNA to pre-miRNAs have been linked to several human cancers including lung adenocarcinoma, ovarian cancer, bladder cancer, breast cancer, thyroid carcinoma, and pineoblastoma [136,137,138,139,140,141].