For example, mutations (e.g., E518K, rs417309 G/A, p.R32fs, copy-number loss, p.S92fsa) in DGCR8, a member of the nuclear microprocessing complex which binds pri-miRNAs to facilitate processing by DROSHA has been linked to various human cancers including Wilms tumor, thyroid carcinoma, FMGS, laryngeal cancer, breast cancer, and pineoblastoma [132,133,134,135,136]. Here, DROSHA is linked to pineoblastoma.