GPBAR1 and uveitis: Moreover, given that decreased levels of secondary bile acids have been detected in serum and faeces of experimentally induced uveitis mice [85], a re-establishment of optimal bile acid levels is sufficient to attenuate disease symptoms and reduce nuclear factor-kappa B (NF-kB) activation in dendritic cells mainly by modulating TGR5 (the bile acid membrane receptor) signalling [85].