It was also reported that ATF3 represses brucine-induced glioma cell ferroptosis by upregulating NOX4 and SOD1 to reduce ROS [125] and inhibits IRI-induced cardiomyocyte ferroptosis by transcriptionally inducing Fanconi anemia complementation group D2 (FANCD2) to affect the expression of GPX4, SLC7A11, FTH1, and PTGS2 [126]. Here, FTH1 is linked to central nervous system cancer.