SELENOW and breast cancer: It was found in breast cancer cells that piR-36712 inhibits SEPW1 expression by binding to SEPW1P (a retroprocessed pseudogene of SEPW1) RNA, blocking its competition with SEPW1 mRNA for miR-7 and miR-324, and it subsequently suppresses the ubiquitination of p53, enhancing the levels of p53 and its target p21 [174].