Regarding IDD gene therapy strategy, regulation of TNF-1 receptor (TNFR-1) and IL-1 receptor (IL1R-1) signaling by the CRISPR lentivirus epigenome editing system was tested in NP and AF cells of degenerating human IVDs to suppress overexpression of TNFR-1 and IL1R-1, and related inflammatory responses [40]. This evidence concerns the gene IL1R1 and intervertebral disk degenerative disorder.