Hepcidin deficiency leads to unregulated ferroportin activity, thus cellular transport of iron into the plasma increases, which can cause chronic liver disease due to cellular iron overload, IDA, congenital dyserythropoietic anaemias, sideroblastic anaemias, β-thalassaemia and myelodysplastic syndromes [86,87]. This evidence concerns the gene SLC40A1 and Tangier disease.