Although the morbidity factors of various autoimmune disorders remain unclear, the abnormal upregulation of type-I IFN has been linked to a spectrum of autoimmune disorders termed “type-I IFN interferonopathies” [144]; thus, the cGAS–STING pathway, which is primarily responsible for producing type-I IFN, is likely to be involved in these disorders. The gene discussed is CGAS; the disease is autoimmune disease.