EGFR and non-small cell lung carcinoma: In fact, several studies in NSCLC have reported that other signalling pathways mediate potential resistance to EGFR-TKIs; for example, activation of JAK2-related signalling upregulated ROR1 via NKX2-1, resulting in the overexpression of NOTCH1, leading to epithelial-to-mesenchymal transition (EMT).