In pediatric hepatoblastoma and hepatocellular carcinoma, VEGF-D secreted by the reactive ductules (cells with a ductular phenotype that proliferate and accumulate in response to liver damage) was associated with a higher number of CD34+ (a marker of proliferating endothelial cells), blood vessels compared to low VEGF-D expressing hepatic tumors [144]. Here, VEGFD is linked to hepatocellular carcinoma.