VEGFD and breast cancer: Interestingly, other forms of anticancer therapies, such as docetaxel and vinorelbine, also upregulate VEGF-D expression and induced angiogenesis in vitro in HUVEC and BC cells in relation to melatonin signaling [124]; this further indicates that VEGF-D has a unique yet unidentified expression and signaling pattern which should be explored to facilitate multi-targeted antiangiogenic therapy.