Many researchers have made significant contributions to this research area by identifying numerous related mechanisms using animal models (ApoE−/− mice and LDLr−/− mice) of atherosclerosis, which have been induced by the knockout of specific genes, including Apolipoprotein E (ApoE) and LDL-receptor (LDLr) [9,10,11]. This evidence concerns the gene LDLR and atherosclerosis.