Another lncRNA, MacORIS (macrophage-enriched obesity-associated long intergenic non-coding RNA serving as a repressor of IFN-γ signaling), is human macrophage-specific and regulates the interferon γ (IFN-γ) signaling-induced Janus kinase 2 (JAK2) alongside the phosphorylation of signal transducer and activator of transcription 1 (STAT1) in THP-1 macrophages [18]. The gene discussed is JAK2; the disease is obesity due to melanocortin 4 receptor deficiency.