AKT1 and obesity due to melanocortin 4 receptor deficiency: Others have associated the upregulation of miR-642a-3p as an invasion/metastasis associated miRNA via the mTOR and PI3K-AKT signaling pathways in gallbladder cancer [20], whereas, in breast cancer, miR-642a-3p expression increases in the breast milk extracellular vesicles of mothers with obesity and is associated with cancer signaling pathways [21].