In addition, Rimeporide has been shown to increase mitochondria respiratory functions with reduced mitochondrial permeability transition [46] and increased biogenesis [47] in myocardial infarction models, which were associated with a decreased mitochondrial vulnerability to exogenous Ca2+ mediated by Na+/Ca2+ exchanger (NCX) activity coupled with NHE1 stimulation [46,48]. The gene discussed is SLC9A1; the disease is myocardial infarction.