Figure 5A showed that the RIM-treated mice showed a 1.4-fold increase in MBP protein expression (p < 0.01) and a 2.9-fold increase in the APC+ mature OL counts (p < 0.01) in both hemispheres of the CC compared to the Veh-treated mice (Figure 5A). Concurrently, the RIM-treated mice also exhibited an increased OL genesis with higher NG2+Olig2+ OPC counts (p < 0.01), reduced Caspase3+Olig2+ OL apoptosis (p < 0.0001), and enhanced H3K9me3+Olig2+ OL differentiation (p < 0.001) in both hemispheres of the CC at 3 d post-stroke (Figure 5B). This evidence concerns the gene APC and Stroke.