In addition, Rimeporide has been shown to increase mitochondria respiratory functions with reduced mitochondrial permeability transition [46] and increased biogenesis [47] in myocardial infarction models, which were associated with a decreased mitochondrial vulnerability to exogenous Ca2+ mediated by Na+/Ca2+ exchanger (NCX) activity coupled with NHE1 stimulation [46,48]. Here, SLC8A1 is linked to myocardial infarction.