Selective deletion of microglial Nhe1 in Cx3cr1-CreER+/−; Nhe1flox/flox mice reduced microglial pro-inflammatory responses, elevated their phagocytic activity, enhanced synaptic pruning, and improved white matter myelination, altogether contributing to significant neurological function recovery after ischemic stroke [13,26]. This evidence concerns the gene SLC9A1 and ischemic stroke.