In this work, lymph node metastasis in skin cutaneous melanoma was associated with CXCL2, in liver hepatocellular carcinoma with CXCL5, in kidney renal clear cell carcinoma with PPBP, and in esophageal carcinoma with CXCL8/IL-8. The gene discussed is CXCL2; the disease is carcinoma of esophagus.