In this work, lymph node metastasis in skin cutaneous melanoma was associated with CXCL2, in liver hepatocellular carcinoma with CXCL5, in kidney renal clear cell carcinoma with PPBP, and in esophageal carcinoma with CXCL8/IL-8. This evidence concerns the gene CXCL5 and carcinoma of esophagus.