The guidelines from the ESC recommend measuring non-HDL-C and ApoB in all patients with high TG levels, diabetes, and obesity, while the American Heart Association/American College of Cardiology/Multisociety guidelines [24] suggest not routinely measuring ApoB, considering cost-effectiveness issues, and recommend performing this test when TG levels ≥ 200 mg/dL [20]. The gene discussed is APOB; the disease is obesity due to melanocortin 4 receptor deficiency.