CFTR and cystic fibrosis: Prior to the era of CFTR, the so-called intermediate conductance outwardly rectifying Cl− channel ICOR (ORCC, ORDIC) was shown in many reports to be the essential epithelial secretory Cl− channel that is absent in cystic fibrosis [86,87,88,89,90,91,92], while others identified the ICOR as a patch clamp artifact occurring during membrane excision [93].