SNCA and Parkinson disease: Here, we present a summary of the impact of point mutations in the SNCA gene (V15A, A18T, A29S, A30P, E46K, H50Q, G51D, A53E, A53T, A53V) associated with monogenic PD, focusing on their effects on α-syn aggregation and, in particular, their interaction with lipids (Table 1).