CTNNB1 and hepatocellular carcinoma: A unique look at HCC tumors that were specifically HCV-associated produced a new and different classification schema which identified four subclasses: CTNNB1 activated, proliferation (IGF1R and ribosomal protein 6 (RPS6) phosphorylation enriched), Interferon-stimulated targets, and Polysomy 7 with upregulation of that chromosome’s respective genes [49].