The enrichment analysis of RNAseq automatic Gene Expression Omnibus (GEO) signatures revealed that active compounds of S. polyrhiza (730 target genes) were associated with mouse down gene set including Atopic Dermatitis Nestin-Cre IKK2 (GSE109936) [14] (Supplementary Data S6, Figure S2). The gene discussed is NES; the disease is atopic eczema.