This is the case of the Akt pathway, whose kinase activity can be increased by inhibitors of the expression of the PTEN tumor suppressor, such as miR17-92, miR-19a/b or miR-221-3p [33,34,35] or silenced by miR-208a and miR-489, which block phosphoinositide 3-kinase (PI3K) and spindlin-1 (SPIN1), respectively [36,37]. Here, SPIN1 is linked to neoplasm.