F13A1 and myocardial infarction: This was further corroborated by the observation that plasma FXIIIA levels significantly drop in the first hours after MI [104], and appropriate circulating levels of FXIIIA molecules or F13A1 gene variants can contrast the unrestrained MMPs action in MI patients [105,106,107], or in fibroblast cell culture adjuvating wound healing in several chronic skin lesions [108,109,110].