FXIII is also essential for other important tasks, such as the recruitment of adult stem cells and neo-angiogenesis by inhibition of the potent anti-angiogenic factor thrombospondin-1 (TSP-1) [150,151], so that dynamic of FXIIIA during the first hours after MI can be considered a prognostic indicator of the infarct evolution [104,122]. The gene discussed is THBS1; the disease is myocardial infarction.