In the context of the alveolar macrophage population, the maintenance of the activation of pathway regulated by PPARγ (peroxisome proliferator-activated receptor gamma) has a fundamental role in the containment of lung inflammatory process, and in the resolution of acute phase, while on the contrary an important PPARγ repression was been demonstrated during activation of lung monocyte-macrophages in severe COVID-19 [28]. Here, PPARG is linked to COVID-19.