In detail, digital pathology based immunohistochemistry demonstrated a mean count of CD68(+) macrophages in SARS-CoV-2 negative controls of 59.43 ± 20.42 SEM, versus mean count of 316.15 ± 34.63 SEM, and 314.92 ± 36.24 SEM in Spike-1 negative and Spike-1 positive COVID-19 deceased patients respectively (Table 1), comparison were significant (Figure 9). This evidence concerns the gene CD68 and COVID-19.