The efficacy of Tf-ELE/CTX@BLIP was indicated by a decrease in the average tumor fluorescence intensity following intravenous administration (65.2, 12.5, 22.1, 6.6, 2.6, and 1.5-times less) compared to the control, CTX solution, ELE solution, ELE/CTX@LIP, ELE/CTX@BLIP, and Tf-ELE/CTX@LIP groups, respectively. Here, TF is linked to neoplasm.