CLOCK and cardiovascular disorder: An appreciation of the nature of this evolutionarily well-preserved endogenous biological clock system and its response to aforementioned environmental stresses of altered diet, sleep/wake architecture, and psychosocial stress are critical in understanding (a) how such stresses alter cardiometabolic function (induce pathology) and (b) the physiological mechanisms contributing to/driving the effectiveness of circadian-timed bromocriptine-QR therapy for cardiovascular disease.