This body of work may be summarized as follows: An attenuation of the circadian peak dopaminergic activity at the CNS clock circuitry programs an activation of noradrenergic and serotonergic input activities at the VMH, which initiates multiple downstream neuroendocrine events leading to cardiometabolic syndrome (hypertension, obesity, insulin resistance, glucose intolerance, dyslipidemia), largely independent of alteration in feeding behavior. Here, CLOCK is linked to metabolic syndrome.