These disproportionate levels of anti-angiogenic factors (sFlt-1 and sEng) and pro-angiogenic factors (PlGF, VEGF, and TGF-β) cause maternal endothelial dysfunctions, further leading to the development of renal endotheliosis, hypertension, and blood coagulation [3,13,24]. The gene discussed is PGF; the disease is endothelial dysfunction.