BDNF and glaucoma: After acute insults, BDNF is able to exert a neuroprotective phenotype where BDNF injections significantly delay microglial activation post-ON sectioning [145], LC cells and astrocytes increase NT secretions after acute ischemia [131], mimicking the hypoxic microenvironments in the ONH during glaucoma, and activated microglia are known to initially release NGF, NT-4/5, and GDNF [146].