MYBPC3 and cardiac hypertrophy: Certain variants are “high-risk” in that they are associated with a more unfavorable prognosis, such as mutations in the MYH7 converter region [27,28] or the c.2737+1 (IVS26) G>T mutation in the MYBPC3 gene (leading to exon 26 skipping, resulting in severe ventricular hypertrophy and a high risk of SCD) [29].