Given this observation, we performed a siRNA-mediated downregulation of KLK-10 expression in cells (Figure 4D,E) and executed a wound healing assay in the presence or absence of picrasidine J. As observed in Figure 4F–I, the treatment with both picrasidine J and siRNA caused a further reduction in cancer cell motility compared to that achieved by the picrasidine J treatment alone. Here, KLK10 is linked to cancer.