Stratification by PNPLA3 gene variant status, which has been shown to influence liver disease from simple steatosis to MASH, fibrosis and hepatocellular carcinoma [12], revealed a clear correlation between IL-32 and disease severity of MASH in PNPLA3 variant carriers, which is in agreement with a report by Baselli et al. [9]. This evidence concerns the gene IL32 and liver disorder.