This STAT3 pathway leads to the creation of hypoxia-inducible factor-1 alpha (HIF-1α), the stimulation of Treg cells and the synthesis of vascular endothelial growth factor (VEGF), and VEGF then further alters the vasculature and inhibits DC development, antigen presentation and T-cell infiltration into tumours [22]. This evidence concerns the gene STAT3 and neoplasm.