Oncostreams, which are fascicles of aligned spindle-like cells that facilitate the intratumoural distribution of tumour cells, depend on the overexpression of collagen, alpha 1, type I (COL1A1), the gene that encodes the major component of type I collagen; so, the inhibition of COL1A1 has been shown to reprogramme the malignant behaviour of gliomas and alter the TME, highlighting oncostreams as yet another high-value target which can possibly be exploited by immunotherapies for gliomas [95]. The gene discussed is COL1A1; the disease is glioma.