Compared with the high group, the low FMGsScore group had higher enrichment in tumor- and immune-related pathways, such as primary immunodeficiency, B-cell receptor signaling pathway, chemokine signaling pathway, cytokine receptor interactions, natural killer cell-mediated cytotoxicity, JAK/STAT signaling pathway, T-cell receptor signaling pathway, etc. (Supplementary Figure S4B). The gene discussed is SOAT1; the disease is inborn error of immunity.