Among the genes specifically essential for the survival and proliferation of KMT2A-r ALL cells we found PSIP1 and CREBBP (Figure 1E), as well as FLT3 (Figure 1F), representing known vulnerabilities in KMT2A-r ALL [33,34,35,36,37,38,39,40,41,42]. This evidence concerns the gene CREBBP and acute lymphoblastic leukemia.