These observations clearly emphasize the validity of our screens and the newly identified genetic dependencies in KMT2A-r ALL, including the epigenetic regulators MBD3 and ARID4B (Figure 1C,E), and the kinases BMPR2, ACVR1, BMPR1A, and STRADA (Figure 1D,F). This evidence concerns the gene ACVR1 and acute lymphoblastic leukemia.