Additionally, a recent report showed that glycogen synthase kinase-3α (GSK-3α) mediates the upregulation of transcription of genes related to fatty acid uptake and storage through PPARα phosphorylation at Ser280 in high-fat diet-induced lipotoxic cardiomyopathy [184], which showed similar FA metabolic changes to those in diabetic cardiomyopathy. The gene discussed is PPARA; the disease is diabetic cardiomyopathy.