Meanwhile, as a feedback, the alterations of phosphorylated AMPK could regulate STIM1-mediated SOCE by influencing STIM1 phosphorylation [161] (Figure 4➄), but the effects seem not strong enough to reverse markedly increased/reduced STIM1 in cardiac hypertrophy/diabetic cardiomyopathy. The gene discussed is STIM1; the disease is diabetic cardiomyopathy.