STIM1 and diabetic cardiomyopathy: Interestingly, the expression of STIM1 has been shown to decrease in diabetic cardiomyopathy [30,31] (Figure 1), and the cardiomyocyte-restricted deletion of STIM1 causes the same characteristics of metabolic changes as appeared in diabetic cardiomyocytes [32,33,34,35,36], which prompts us to consider the relevance of STIM1 in the regulation of cardiac energy substrate switch.