STIM1 and cardiac hypertrophy: Given that there is an increase in glucose uptake and glycolysis in cardiac hypertrophy [120], glucose itself and some by-products (e.g., methylglyoxal, pyruvic acid) from glucose metabolism are able to modify STIM1 (e.g., N-glycosylation) and increase SOCE [95,152,154,155] (Figure 4➆); therefore, STIM1-mediated SOCE could be further enhanced, accelerating the development of cardiac hypertrophy.