Together with the fact that reduced STIM1 expression is also associated with impaired insulin-induced glucose uptake in other types of cells [127,138], we guess that decreased STIM1 might contribute to impaired glucose uptake by inhibiting the insulin pathway in diabetic cardiomyopathy, while increased STIM1 may upregulate insulin-induced glucose uptake via enhancing AKT phosphorylation in cardiac hypertrophy (Figure 4➁). Here, INS is linked to diabetic cardiomyopathy.