SLC2A1 and neuroblastoma: However, Olianas et al. showed that STIM1 knockdown inhibited Gq/11-coupled muscarinic acetylcholine receptors-induced glucose uptake in human SH-SY5Y neuroblastoma cells [134], and they also found that in human SH-SY5Y neuroblastoma cells, STIM1-mediated SOCE stimulated AMPK by phosphorylation at Thr 172, and it also increased glucose uptake and the membrane expression of the GLUT1 [135], revealing a positive role of STIM1 in glucose uptake via AMPK phosphorylation and the regulation of GLUT expression.