STIM1 and cardiac hypertrophy: Consequently, a lower STIM1 expression in diabetic cardiomyopathy could be responsible for the impaired glucose uptake by diminishing AMPK phosphorylation at Thr172, while a higher STIM1 expression in cardiac hypertrophy could increase AMPK phosphorylation at Thr172 to enhance glucose uptake (Figure 4➂).