CLU and early-onset autosomal dominant Alzheimer disease: The human homolog of clusterin has been given numerous acronyms, including SP-40,40 protein (identified in the human SC5b complex of complement and in immune deposits in glomerulonephritis) [6], apolipoprotein J [7] and complement lysis inhibitor (CLI) [8] (human lipoprotein associated with high- and very-high-density lipoproteins in human serum and plasma), pADHC-9 (human mRNA from the hippocampus of Alzheimer’s disease patients) [9] and pTB16 (human mRNA highly expressed in epileptic foci) [10].