As for MYC, MYB is a family of transcription factors that comprises the tissue specific c-MYB and A-MYB, and the ubiquitous B-MYB, a positive regulator of cell proliferation, differentiation and survival that is overexpressed in various types of human cancers including human neuroblastomas, suggesting that it functions as a proto-oncogene. The gene discussed is MYB; the disease is neuroblastoma.