MYCN and head and neck squamous cell carcinoma: Works carried out in head and neck squamous cell carcinoma (HNSCC) revealed that the CLU mRNA is a specific and functional target of oncogenic miRNA-21 [85], while in neuroblastoma, CLU is strongly downregulated by MYCN, at least in part through transcriptional induction of the miR-17-92 microRNA cluster [86].