IL1B and rheumatoid arthritis: When we analyzed if the pro-inflammatory mediator and atrogenes were modulated, we observed that the arthritic insult led to an increase in IL-1β mRNA levels (1.96 ± 0.18 vs. 0.99 ± 0.3 healthy, p < 0.01), and TOFA tended to restore the values (1.44 ± 0.27 vs. 1.96 ± 0.18 e-RA, p = ns) (Figure 4A).