When atrogenes were analyzed, e-RA animals exhibited an upregulation of both atrogin-1 (1.72 ± 0.25 vs. 1 ± 0.11 healthy, p < 0.01) and MuRF-1 (1.80 ± 0.32 vs. 1 ± 0.10 healthy, p < 0.05), which was completely restored with TOFA (0.94 ± 0.15 vs. 1.72 ± 0.25 e-RA atrogin-1, p < 0.05, and 0.93 ± 0.26 vs. 1.80 ± 0.26 e-RA MuRF-1, p < 0.01) (Figure 4B). Here, TRIM63 is linked to rheumatoid arthritis.