Mean values of serum concentrations of HMGB1 and HO-1 determined in mild/moderate COVID-19 patients on admission to the hospital (Table 1) show that there was already a statistically significant increase in their concentrations in the first days of COVID-19 disease, especially of HMGB1, compared with non-COVID-19 subjects. The gene discussed is HMGB1; the disease is COVID-19.