MAPT and Alzheimer disease: PD, like AD, also includes altered exosomal cargo profiles, including altered levels of miRs (miR-153, miR-409-3p, miR-10a-5p, and let-7g-3p), mRNAs of the amyloid precursor protein, α-syn, Tau, neurofilament light gene, DJ-1/PARK7, and long non-coding RNAs (RP11-462G22.1 and PCA3) in EXs in cerebral spinal fluid [68], suggesting that cerebral spinal fluid exosomal RNA molecules could serve as biomarkers in regard to specificity and sensitivity in differentiating PD from healthy controls.