A glucose-responsive microgel composed of an acid-responsive chitosan matrix, GOx/catalase (CAT) nanocapsules, and recombinant human insulin demonstrated, in six streptozotocin-induced type 1 diabetic mice, a prolonged self-regulated profile of insulin release as a function of glucose concentration for encapsulated microgel [28]. Here, CAT is linked to type 1 diabetes mellitus.