INS and Hypoglycemia: On the clinical outcomes of bi-hormonal insulin/glucagon or insulin/pramlintide (synthetic analogue of amylin, a small peptide hormone that is circulated by pancreatic β cells together with insulin to counteract postprandial hyperglycaemic peaks [86]) AID, a recently published meta-analysis reviewed 17 studies involving a total of 438 patients, comparing bi-hormonal AID systems to insulin-only ones, as well as bi-hormonal systems using simple pump with or without predictive low-glucose suspension for hypoglycaemia [87].