TGM2 and liver disorder: The titers of tTG-IgA antibodies in ALD patients (median 1.93 U/L [IQR 1.34–2.65 U/L]) were significantly higher than those in the healthy controls (median 0.34 U/L [IQR 0.24–0.54 U/L], p < 0.0005) or in the alcoholics without liver disease (median 0.45 U/L [IQR 0.30–0.65 U/L], p < 0.0005) (Figure 1A).