In line with previous research examining the relationship between IL-6 levels and cardiovascular event risk, IL-6 concentrations were associated with an increased risk (OR: 1.4, 95% CI: 1.1–2.2) of adverse vascular events, including stroke, cardiovascular events and/or vascular death in a 24-month longitudinal study with 130 functionally independent SVD patients [71]. The gene discussed is IL6; the disease is snowflake vitreoretinal degeneration.