In a cross-sectional study with 293 thrombolysed acute ischaemic stroke patients, higher serum VEGF levels at 90 days post-stroke, though not baseline levels at stroke onset, were associated with the presence of lacunes and greater global SVD disease burden on CT after adjusting for age, sex, and vascular risk factors; there was no association with WMH burden specifically [40]. The gene discussed is VEGFA; the disease is stroke disorder.