In 1422 lacunar stroke patients with no prior history of cortical stroke or carotid stenosis, patients in the highest quartile of circulating CRP levels measured in the subacute post-stroke phase (median: 60 days) had more than twice the risk of recurrent ischaemic stroke at 3-year follow-up (OR: 2.32, 95% CI: 1.15–4.68) after adjusting for age, sex, race-ethnicity, history of cardiac disease, vascular risk factors and statin use [91]. The gene discussed is CRP; the disease is ischemic stroke.