In 1763 stroke-free participants in the Framingham Heart Study, Shoamanesh et al. [44] observed higher levels of circulating Lp-PLA2 in participants with lacunes and greater WMH volumes, as well as a non-significant trend between higher levels of Lp-PLA2 and the increasing number of microbleeds after adjusting for age, sex and vascular risk factors. This evidence concerns the gene PLA2G7 and Stroke.