Univariate analyses revealed lower levels of VEGF in patients in an MRI subgroup with widespread WMH and lacunes, microbleeds, atrophy and severe cognitive and gait impairments compared to 21 healthy controls or those in the other MRI subgroup, categorised by more severe deep WMH, lacunes in the white matter, no microbleeds or atrophy and less severe clinical manifestations, though the latter was not statistically significant. The gene discussed is VEGFA; the disease is Atrophy.