VWF and snowflake vitreoretinal degeneration: Average vWF levels were higher in a group of 74 recent lacunar stroke patients compared to 74 controls matched for age, sex, hypertension and diabetes; however, vWF levels had significantly decreased by 3 months post-stroke and were at comparable levels between groups, perhaps suggesting that chronic vWF elevation was not playing a central role in SVD pathophysiology [38].