For instance, CRP activity can inhibit angiogenesis, promote atherosclerosis, mediate circulating cytokine levels, inhibit NO, decrease endothelial nitric oxide synthase (eNOS) activity in endothelial cells, increase Endothelin-1 production, attenuate endothelial-dependent vasodilation and increase endothelial cell adhesion molecule expression, including VCAM-1 and E-selectin [87,88,89]. The gene discussed is NOS3; the disease is atherosclerosis.