LGALS3 and hydrops fetalis: Gal-3 stimulates pathological remodeling and development of fibrosis, mainly by inducing fibroblast proliferation and collagen deposition, and, therefore, is called a “culprit” biomarker in HF in contrast to “bystanders” biomarkers, such as N-terminal pro-B-type natriuretic peptide (NT-pro BNP) or C reactive protein [7].