VIM and HIV-1 infection: Moreover, the phosphorylated HIV-1 Pr55Gag matrix protein (MA) is mainly associated with the HIV-1 PIC and with the actin cytoskeleton during the early stages of HIV-1 infection in T-cell lines, determining the localization of reverse transcription to actin microfilaments that was mediated by the interaction of a reverse transcription complex component (Pr55Gag-MA) with actin but not vimentin (IFs) or tubulin (MTs).