An interesting observation, which demonstrates the relevance of the acetylation PTM of MTs for productive HIV-1 infection, was the fact that silencing of the endogenous TDP-43/HDAC6 axis significantly favored the infectivity of primary Envs of viruses isolated from VNP and RP HIV-1 patients and strongly increased the infection of those from LTNP-EC that in control conditions are inefficient for infection [71]. This evidence concerns the gene TARDBP and infection.