ERVW-1 and HIV-1 infection: The overexpression of wild-type PI4P5-K Iα increased HIV-1 Env-mediated PIP2 production and enhanced viral replication in primary lymphocytes and a CD4+ T-cell line, whereas PIP2 production and HIV-1 infection were both severely reduced in cells overexpressing a kinase-dead mutant D227A (D/A)-PI4P5-K Iα [96].