Therefore, HIV-1 uses moesin and filamin-A to promote the aggregation of HIV-1 receptors in a pole of the cell, thereby regulating CD4/CXCR4-CCR5 diffusion at the cell surface in an actin cytoskeleton-dependent manner [80,109,114,119] to facilitate the first events of the infection process (Figure 2). The gene discussed is CCR5; the disease is infection.