PPIA and infection: The uncoating process of the viral capsid could be detrimental to infection if it exposes the viral genome before entry into the nucleus of cells [15,136,139,143,144,145], as reported for nonstable HIV-1 viral capsids [143,146,147,148], which are the main antiviral function of the classical tripartite motif containing 5 alpha (TRIM5a) restriction factor [149,150], cyclophilin A [151], and Trim5-cyclophilin A fusion protein (TRIMCyp) [152].