CXCR4 and HIV-1 infection: In fact, gelsolin appears to be essential for efficient and productive HIV-1 infection by regulating the size of preformed AFs by cleaving them into short filaments that allow the actin cytoskeleton to reorganize together with CD4/CXCR4-CCR5 aggregation at pseudopods, where the virus enters and infects CD4+ T cells [114].