Therefore, because the fusion peptide of the HIV-1 gp41 viral protein is thought to insert into target membranes [191,192,193,194] to mediate lipid exchange between HIV-1 and plasma membrane lipid bilayers, producing a fusion pore at the viral-cell contact region, the anti-HIV-1 effect exerted by the tubulin-deacetylase HDAC6 could be due to the impediment to establish an HIV-1 gp41/plasma membrane/acetylated MT “tension zone” during the early steps of the infection process. The gene discussed is HDAC6; the disease is infection.