AKT1 and hepatocellular carcinoma: Our literature search showed that commonly dysregulated miRNAs in HBV-associated HCC include upregulated mir-18a, mir-21, mir-221, and mir-222 and downregulated mir-26a, mir-125, mir-122 [8,69,70,71,72], which combined target-to-target pathways involved in the increased proliferation and reduced apoptosis in HCC, such as WNT/beta-catenin, PI3K/Akt, MAPK, TP53, and JAK/STAT [73].