The increase in the expression of SEMA3E was also observed when cells were exposed to other chemotherapeutic agents such as carboplatin, adriamycin, mitomycin C, etoposide and radiation (UV and X-ray), all of which implies that cancer cells may upregulate SEMA3E as a survival mechanism to prevent cell death induced by chemotherapy or radiotherapy [59]. Here, SEMA3E is linked to cancer.