SEMA3B also promotes cancer cell apoptosis by increasing cytochrome c release and caspase-3 cleavage and inactivates proapoptotic proteins such as glycogen synthase kinase-3β, forkhead in rhabdomyosarcoma (FKHR) and mouse double minute 2 homolog (MDM-2) [19]. The gene discussed is SEMA3B; the disease is cancer.