Previous studies showed that SAMP8 mice exhibit several AD pathological features in the hippocampus and other brain regions, including increased amyloid-β (Aβ) protein precursor, increased Aβ protein, amyloid-like plaque deposits, hyperphosphorylation of Tau protein, decreased dendritic spine density, gliosis, reduced neurotrophic factors, and neuronal loss [25,44,45]. This evidence concerns the gene MAPT and Alzheimer disease.