MET and neoplasm: The reasons for that may be: (1) the high rate of false negatives by targeted NGS techniques in identifying MET-GCNG due to duplication of the whole chromosome 7 or parts of it larger than the MET region; (2) the subclonal nature of MET-amplified tumor cells in NSCLC, which can be captured by direct morphological assessment using FISH but may be “diluted” by DNA of other cells.