CDK4 and neoplasm: This time a tissue rebiopsy from metastasis in axillar lymph nodes was feasible and revealed acquired MET amplification (average MET-GCN/cell = 8.3, as assessed by FISH) and overexpression (MET-IHC 3+ in 60% and 2+ in 40% of tumor cells) together with high-level amplification of three other genes (detected by NGS): PDGFR-A (26 copies) on chromosome 4, MYC (26 copies) on chromosome 8, and CDK4 (25 copies) on chromosome 12.