MET and non-small cell lung carcinoma: In any case, in keeping with our current data, FISH, despite being relatively laborious and observer-dependent [62], remains the most reliable method for detecting MET amplification in clinical NSCLC tissue samples with high sensitivity, minimal false negative rate, and the possibility of distinguishing MET-GCNG due to focal amplification of the MET genomic region on chromosome 7 from GCNG due to polysomy.