A 75-year-old female, smoker (20 py), in a PS of 2, with well-treated hypertension, was diagnosed with LAC in the right lung’s lower lobe with multiple brain and bone metastases and EGFR ex19del (p.E746_A750del) and TP53 (c.673-2A>G, p. potentially affecting the 5’ end splice site of exon 7) co-mutations. The gene discussed is TP53; the disease is Hypertension.