TP53 and neoplasm: Rebiopsy from the relapsed tumor in the right pulmonary upper lobe showed an acquired TP53 mutation (p.L265P) and high-level MET amplification (average MET-GCN/cell = 9.9 and 15% of tumor cells with MET clusters; Figure 7) as well as MET protein upregulation (3+ in 30% and 2+ in 70% of tumor cells) detected by FISH and IHC, respectively, while NGS did not detect the MET amplification.