An 80-year-old male, in PS 2, former light smoker (2 py), with significant comorbidities (hypertension, diabetes type 2, hypercholesterolemia, and previous apoplexy without sequels), was diagnosed in 2016 with right malignant pleural effusion containing metastatic LAC cells with EGFR p.L858R mutation. Here, EGFR is linked to familial hypercholesterolemia.