TUSC2 and cancer: On a more basic biochemical level, errant calcium signalling is pivotal in inflammation and cancer, and is highlighted by the loss of a tumour suppressor gene, FUS1/TUSC2, which encodes for a mitochondrial protein, leading to reduced mitochondrial calcium accumulation and hyperactivation of factors like NFAT and NF-KB: this is associated with low respiratory reserve, increased inflammation, senescence and accelerated ageing [275].