NLRP3 and metabolic dysfunction-associated steatotic liver disease: To study the role of NLRP3 inflammasomes in NAFLD, both loss-of-function and gain-of-function Nlrp3 mice models had been produced, and research has confirmed that Nlrp3 deficiency provides protection against diet-induced steatohepatitis, liver enlargement, liver injury, and activated macrophage infiltration, and vice versa [65].