NLRP3 and fatty liver disease: Studies have demonstrated that Nlrp3−/−, Asc−/−, and Casp-1−/− mice fed with a high-fat diet (HFD) exhibited diminished weight gain, reduced hepatic steatosis development (particularly in Asc−/− mice), improved quality of epididymal adipose tissue with decreased adipocyte size, and enhanced insulin sensitivity [64].