The additional mutations in the aHUS spectrum are mainly heterozygous complement factor H mutations (CHF spectrum, cases 1, 2, 4, 7, 8), CD 46 (cases 2, 3, 4, 6, 8), C3 (cases 1,4), and one homozygous CFH H3 mutation (case 5) (Appendix A). Here, C3 is linked to congestive heart failure.