CFH and congestive heart failure: The additional mutations in the aHUS spectrum are mainly heterozygous complement factor H mutations (CHF spectrum, cases 1, 2, 4, 7, 8), CD 46 (cases 2, 3, 4, 6, 8), C3 (cases 1,4), and one homozygous CFH H3 mutation (case 5) (Appendix A).