PRRT2 and diabetic kidney disease: Increased intercellular level of glucose activates several metabolic pathways (namely polyol pathway, hexosamine pathway, protein kinase C (PKC) pathway, AGE pathway, and Rho-associated coiled-coil containing protein kinase (ROCK) pathway), which results in redox imbalance that is a starting point for DKD progression [30,31] (Table 1).