E. J. Weil et al. in their study of patients with type 2 diabetes mellitus found that both podocyte damage and glomerular endothelial injury were present in a cohort with macroalbuminuria but, interestingly, compared with podocyte injury, endothelial abnormalities were more closely associated with increasing urine albumin excretion. This evidence concerns the gene ALB and type 2 diabetes mellitus.