Studies focusing on miR-223 target genes showed that PARP-1 suppression by miR-223 is involved in the resolution of pneumonia, in that miR-223 deficiency was associated with severe lung inflammation, whereas pulmonary overexpression of miR-223 in mice resulted in protection during acute lung injury-induced by mechanical ventilation or by infection [40]. This evidence concerns the gene PARP1 and pneumonia.