Another ED-related factor contributing to hypercoagulability in cirrhosis is the significantly increased production of endothelium liver-independent coagulation or anticoagulation factors such as Factor (F) FVIII, von Willebrand factor (vWF), and plasminogen activator inhibitor 1 (PAI-1) [30,31,32]. Here, SERPINE1 is linked to thrombophilia.